TABLE 2.
The potential metabolic pathways
| Total | Expected | Hits | Raw P | #name? | Holm adjust | FDR | Impact | |
|---|---|---|---|---|---|---|---|---|
| Aminoacyl‐tRNA biosynthesis | 69 | 3.6034 | 17 | 1.81 × 10−8 | 17.827 | 1.48E‐06 | 1.48E‐06 | 0.12903 |
| Arginine and proline metabolism | 44 | 2.2978 | 10 | 4.84 × 10−5 | 9.9365 | 0.0039184 | 0.0019834 | 0.36034 |
| Histidine metabolism | 15 | 0.78335 | 4 | 0.0060344 | 5.1103 | 0.48275 | 0.11698 | 0.24194 |
| Alanine, aspartate and glutamate metabolism | 24 | 1.2534 | 5 | 0.0066071 | 5.0196 | 0.52196 | 0.11698 | 0.60232 |
| Purine metabolism | 68 | 3.5512 | 9 | 0.0071327 | 4.9431 | 0.55635 | 0.11698 | 0.23524 |
| Nitrogen metabolism | 9 | 0.47001 | 3 | 0.0091513 | 4.6939 | 0.70465 | 0.12507 | 0 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 4 | 0.20889 | 2 | 0.015078 | 4.1945 | 1 | 0.15742 | 1 |
| Valine, leucine and isoleucine biosynthesis | 11 | 0.57445 | 3 | 0.016665 | 4.0944 | 1 | 0.15742 | 0.99999 |
| Pyrimidine metabolism | 41 | 2.1411 | 6 | 0.017278 | 4.0583 | 1 | 0.15742 | 0.1534 |
| Glycine, serine and threonine metabolism | 31 | 1.6189 | 5 | 0.019841 | 3.92 | 1 | 0.1627 | 0.26989 |
| d‐Glutamine and d‐glutamate metabolism | 5 | 0.26112 | 2 | 0.024285 | 3.7179 | 1 | 0.18103 | 1 |
| Pantothenate and CoA biosynthesis | 15 | 0.78335 | 3 | 0.039543 | 3.2304 | 1 | 0.26972 | 0.02041 |
| Glutathione metabolism | 26 | 1.3578 | 4 | 0.04276 | 3.1522 | 1 | 0.26972 | 0.44179 |
| Cysteine and methionine metabolism | 27 | 1.41 | 4 | 0.048266 | 3.031 | 1 | 0.2827 | 0.17491 |
| β‐Alanine metabolism | 17 | 0.88779 | 3 | 0.054848 | 2.9032 | 1 | 0.29984 | 0 |
| Biosynthesis of unsaturated fatty acids | 42 | 2.1934 | 5 | 0.063642 | 2.7545 | 1 | 0.32333 | 0 |
| Glycerophospholipid metabolism | 30 | 1.5667 | 4 | 0.067032 | 2.7026 | 1 | 0.32333 | 0.15371 |
| Phenylalanine metabolism | 11 | 0.57445 | 2 | 0.10909 | 2.2156 | 1 | 0.49694 | 0.40741 |
| Amino sugar and nucleotide sugar metabolism | 37 | 1.9323 | 4 | 0.12318 | 2.0941 | 1 | 0.53164 | 0.16012 |
| Ubiquinone and other terpenoid–quinone biosynthesis | 3 | 0.15667 | 1 | 0.14873 | 1.9056 | 1 | 0.60979 | 0 |
| Lysine biosynthesis | 4 | 0.20889 | 1 | 0.19328 | 1.6436 | 1 | 0.75471 | 0 |
| Biotin metabolism | 5 | 0.26112 | 1 | 0.23553 | 1.4459 | 1 | 0.86 | 0 |
| Glyoxylate and dicarboxylate metabolism | 18 | 0.94001 | 2 | 0.24122 | 1.4221 | 1 | 0.86 | 0.38709 |
| Cyanoamino acid metabolism | 6 | 0.31334 | 1 | 0.27559 | 1.2888 | 1 | 0.886 | 0 |
| Linoleic acid metabolism | 6 | 0.31334 | 1 | 0.27559 | 1.2888 | 1 | 0.886 | 1 |
| Citrate cycle (TCA cycle) | 20 | 1.0445 | 2 | 0.28093 | 1.2697 | 1 | 0.886 | 0.09164 |
| Sphingolipid metabolism | 21 | 1.0967 | 2 | 0.30076 | 1.2014 | 1 | 0.91341 | 0.01504 |
| Valine, leucine and isoleucine degradation | 38 | 1.9845 | 3 | 0.31867 | 1.1436 | 1 | 0.93324 | 0 |
| Lysine degradation | 23 | 1.2011 | 2 | 0.34013 | 1.0784 | 1 | 0.9556 | 0 |
| Taurine and hypotaurine metabolism | 8 | 0.41778 | 1 | 0.34961 | 1.0509 | 1 | 0.9556 | 0.42857 |
| Ascorbate and aldarate metabolism | 9 | 0.47001 | 1 | 0.38377 | 0.95772 | 1 | 0.9834 | 0 |
| Methane metabolism | 9 | 0.47001 | 1 | 0.38377 | 0.95772 | 1 | 0.9834 | 0.4 |
| Riboflavin metabolism | 11 | 0.57445 | 1 | 0.44686 | 0.80551 | 1 | 1 | 0 |
| Nicotinate and nicotinamide metabolism | 13 | 0.6789 | 1 | 0.50357 | 0.68603 | 1 | 1 | 0.2381 |
| Pentose and glucuronate interconversions | 16 | 0.83557 | 1 | 0.57805 | 0.54809 | 1 | 1 | 0.2 |
| Glycerolipid metabolism | 18 | 0.94001 | 1 | 0.62147 | 0.47567 | 1 | 1 | 0.0256 |
| Starch and sucrose metabolism | 19 | 0.99224 | 1 | 0.64149 | 0.44396 | 1 | 1 | 0.13815 |
| Fatty acid biosynthesis | 43 | 2.2456 | 2 | 0.6688 | 0.40227 | 1 | 1 | 0 |
| Fructose and mannose metabolism | 21 | 1.0967 | 1 | 0.67845 | 0.38794 | 1 | 1 | 0.15342 |
| Butanoate metabolism | 22 | 1.1489 | 1 | 0.6955 | 0.36313 | 1 | 1 | 0 |
| Galactose metabolism | 26 | 1.3578 | 1 | 0.7552 | 0.28077 | 1 | 1 | 0 |
| Fatty acid elongation in mitochondria | 27 | 1.41 | 1 | 0.76823 | 0.26367 | 1 | 1 | 0 |
| Porphyrin and chlorophyll metabolism | 27 | 1.41 | 1 | 0.76823 | 0.26367 | 1 | 1 | 0 |
| Arachidonic acid metabolism | 36 | 1.88 | 1 | 0.85855 | 0.15251 | 1 | 1 | 0.32601 |
| Fatty acid metabolism | 39 | 2.0367 | 1 | 0.88011 | 0.12771 | 1 | 1 | 0 |
| Tryptophan metabolism | 40 | 2.0889 | 1 | 0.88655 | 0.12042 | 1 | 1 | 0.17715 |
| Tyrosine metabolism | 44 | 2.2978 | 1 | 0.90906 | 0.095343 | 1 | 1 | 0.14045 |
| Primary bile acid biosynthesis | 46 | 2.4023 | 1 | 0.9186 | 0.084902 | 1 | 1 | 0.02976 |