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. 2021 Mar 19;21(5):404. doi: 10.3892/ol.2021.12665

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Figure 1. — Signaling pathways in diseases mediated by UCA1. UCA1 regulates key signaling pathways by acting as a competitive endogenous RNA, thus affecting biological activities, such as cell proliferation, apoptosis, migration, invasion and drug resistance in cancers and non-cancerous diseases. UCA1, urothelial carcinoma associated 1; CCND1, cyclin D1; CDK6, cyclin-dependent kinase 6; CLIC1, chloride intracellular channel 1; CREB1, cAMP response element-binding protein 1; CXCR4, C-X-C chemokine receptor type 4; DLL4, Delta-like 4; EZH2, enhancer of zeste homolog 2; HULC, highly upregulated in liver cancer; MEF2C, myocyte enhancer factor 2C; METTL3, methyltransferase-like 3; MMP-9, matrix metalloproteinase-9; mTOR, mammalian target of rapamycin; RAC1, RAS-related C3 botulinus toxin substrate 1; TGF-β, transforming growth factor-β; TIMP2, tissue inhibitor of metalloproteinase-2; YAP, yes-associated protein; miR, microRNA; EMT, epithelial-to-mesenchymal transition; lncRNA, long non-coding RNA.