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. 2021 Mar 18;21(5):391. doi: 10.3892/ol.2021.12652

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Copyright: © Cao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Correlation analysis between BMPR2 expression and the infiltrating immune cells. (A) GSEA was performed (false discovery rate <0.25, nominal P<0.05) in the enrichment of ‘c5.bp.v7.0.symbols.gmtb (Gene Ontology)’. The regulation of the macrophage differentiation pathway and establishment or maintenance of the monopolar cell polarity pathway were mediated by BMPR2 in osteosarcoma. (B) BMPR2 expression level in sarcoma was statistically significant with CD4+ T cell, and negligibly correlated with macrophage and dendritic cell infiltration. (C) Low infiltration of CD4+ T cells and neutrophil cells was correlated with worse survival in sarcoma. BMPR2, bone morphogenetic protein receptor 2; NES, normalized enrichment score.