. 2021 Mar 18;21(5):391. doi: 10.3892/ol.2021.12652

Table III.

Correlation analysis between bone morphogenetic protein receptor 2 and related genes and markers of immune cells in R2 and Tumor Immune Estimation Resource databases.

	OS		SARC

Gene markers	Cor	P-value	Cor	P-value
CD8+ T cell
CD8A	−0.300	0.029	−0.148	0.017
CD8B	−0.288	0.036	−0.183	0.003
T cell (general)
CD3D	−0.109	0.437	−0.267	0.001^a
CD3E	−0.355	0.009	−0.196	0.001
CD2	−0.273	0.048	−0.200	0.001
B cell
CD19	−0.133	0.342	−0.288	0.001^a
CD79A	−0.099	0.479	−0.162	0.009
Monocyte
CD86	−0.543	0.001^a	−0.382	0.001^a
CD115 (CSF1R)	−0.467	0.001^a	−0.316	0.001
TAM
CCL2	−0.099	0.48	−0.197	0.001
CD68	0.312	0.023	−0.453	0.001^a
IL10	0.012	0.933	−0.345	0.001^a
M1 Macrophage
INOS (NOS2)	−0.043	0.761	0.129	0.037
IRF5	−0.385	0.004	−0.325	0.001^a
COX2 (PTGS2)	0.248	0.073	0.149	0.016
M2 Macrophage
CD163	−0.542	0.001^a	−0.347	0.001^a
VSIG4	−0.517	0.001^a	−0.323	0.001^a
MS4A4A	−0.354	0.009	−0.337	0.001^a
Neutrophils
CD66b (CEACAM8)	−0.183	0.190	−0.126	0.043
CD11b (ITGAM)	−0.224	0.106	−0.327	0.001^a
CCR7	−0.228	0.101	−0.082	0.185
Natural killer cell
KIR2DL1	−0.131	0.349	−0.155	0.012
KIR2DL3	−0.169	0.228	−0.142	0.022
KIR2DL4	0.014	0.921	−0.312	0.001^a
KIR3DL1	−0.365	0.007	−0.066	0.289
KIR3DL2	−0.167	0.233	−0.041	0.507
KIR3DL3	−0.258	0.062	−0.119	0.055
KIR2DS4	0.219	0.115	−0.140	0.024
Dendritic cell
HLA-DPB1	−0.201	0.150	−0.294	0.001^a
HLA-DQB1	−0.259	0.061	−0.274	0.001^a
HLA-DRA	−0.484	0.001^a	−0.265	0.001^a
HLA-DPA1	−0.451	0.001^a	−0.238	0.001^a
BDCA-1 (CD1C)	0.235	0.090	0.020	0.752
BDCA-4 (NRP1)	0.183	0.189	0.167	0.007
CD11c (ITGAX)	−0.331	0.015	−0.325	0.001^a
Th1
T-bet (TBX21)	0.197	0.157	−0.204	0.001^a
STAT4	−0.031	0.827	−0.181	0.003
STAT1	−0.166	0.234	0.064	0.303
IFN-γ (IFNG)	−0.216	0.120	−0.216	0.001^a
TNF-α (TNF)	−0.314	0.022	−0.203	0.001
Th2
GATA3	−0.181	0.195	−0.162	0.009
STAT6	0.092	0.514	0.253	0.001^a
STAT5A	−0.483	0.001^a	−0.183	0.003
IL13	−0.320	0.019	−0.030	0.632
Tfh
BCL6	0.099	0.479	0.018	0.771
IL21	0.031	0.825	−0.113	0.070
Th17
STAT3	−0.545	0.001^a	0.448	0.001^a
IL17A	−0.529	0.001^a	0.003	0.961
Treg
FOXP3	−0.171	0.221	−0.126	0.042
CCR8	−0.072	0.608	−0.025	0.689
STAT5B	0.158	0.257	0.365	0.001^a
TGFβ (TGFB1)	−0.045	0.751	−0.4	0.001^a
T cell exhaustion
PD-1 (PDCD1)	−0.133	0.341	−0.237	0.001^a
CTLA4	−0.112	0.424	−0.2	0.001
LAG3	−0.209	0.133	−0.357	0.001^a
TIM-3 (HAVCR2)	−0.599	0.001^a	−0.407	0.001^a
GZMB	−0.324	0.018	−0.409	0.001^a

P<0.001. OS, osteosarcoma; SARC, sarcoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, follicular helper T cell; Treg, regulatory T cell; Cor, coefficient value of Spearman's correlation.