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. 2021 Mar 16;21(5):383. doi: 10.3892/ol.2021.12644

Figure 2.

Figure 2.

Implications of lymph node relapse for prognosis and CCL22 expression. (A) H&E and CCL22 immunohistochemical staining of WPOI-high tumor tissues (scale bar, 100 µm). Comparisons of (B) CCL22+ and (C) CD68+ expression in WPOI-high tissues with or without lymph node relapse. Comparisons of (D) CD8+ cells and (E) Ki67 expression in WPOI-high tissues with or without lymph node relapse (scale bar, 100 µm). (F) Kaplan-Meier survival curves in patients with or without lymph node relapse in the WPOI-high group. In box plots, the boxes display the median and interquartile range of the data, and the whiskers display the 10th and 90th percentiles. Blue diamonds and blue arrows indicate the mean ± SD. *P<0.05; **P<0.01. N.S., not significant; H&E, hematoxylin and eosin; WPOI, worst pattern of invasion; CCL22, C-C motif chemokine ligand 22.