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. 2021 Mar 13;21(5):371. doi: 10.3892/ol.2021.12632

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — LINC00173 is increased in DDP-resistant HCC tissues and cells. (A) Relative LINC00173 expression levels in HCC tissues and adjacent-normal tissues were determined by RT-qPCR; n=30. (B) RT-qPCR analysis of relative LINC00173 expression of in DDP-resistant (Huh7/DDP and Hep3B/DDP) and DDP-sensitive HCC tissues. Cell Counting Kit-8 analysis was used to determine the IC₅₀ value of DDP-resistant (C) Huh7/DDP and (D) Hep3B/DDP cells and their parental cell lines (Huh7 and Hep3B) treated with different concentrations of DDP (0.01, 0.1, 0.5, 1, 5, 25, 50 and 100 µM). RT-qPCR analysis of LINC0017 3expression in DDP-resistant (E) Huh7 and (F) Hep3B cells. (G) Kaplan-Meier survival analysis of the association between LINC00173 expression and the prognosis of patients with HCC. *P<0.05. DDP, cisplatin; HCC, hepatocellular carcinoma; RT-qPCR, reverse transcription-quantitative PCR; IC₅₀, half maximal inhibitory concentration; HR, hazard ratio.