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. 2021 Mar 13;21(5):371. doi: 10.3892/ol.2021.12632

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — miR-641 is a target of LINC00173 in HCC cells. (A) StarBase was used to predict potential binding sites between LINC00173 and miR-641. (B) RT-qPCR analysis of relative miR-641 expression in Huh7/DDP and Hep3B/DDP cells transfected with NC or miR-641 mimics. Luciferase activity of LINC00173-wt or LINC00173-mut in (C) Huh7/DDP and (D) Hep3B/DDP cells transfected with NC or miR-641 mimics. (E) RT-qPCR analysis of relative miR-641 expression in Huh7/DDP and Hep3B/DDP cells transfected with shLINC00173, shNC, pcDNA3.1/LINC00173 and pcDNA3.1. Relative miR-641 expression in (F) HCC tissues and (G) DDP-resistant HCC tissues was determined by RT-qPCR. (H) Pearson's correlation analysis revealed a negative correlation between miR-641 and LINC00173 expression in HCC tissues. *P<0.05. miR, microRNA; HCC, hepatocellular carcinoma; RT-qPCR, reverse transcription-quantitative PCR; DDP, cisplatin; wt, wild-type; mut, mutant; NC, negative control; sh, short hairpin.