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. 2021 Mar 13;21(5):371. doi: 10.3892/ol.2021.12632

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — LINC00173-knockdown decreases DDP resistance in DDP-resistant HCC cells by targeting miR-641. (A) RT-qPCR analysis of relative miR-641 expression in Huh7/DDP and Hep3B/DDP cells transfected with the NC inhibitor or miR-641 inhibitor. (B) RT-qPCR analysis of relative miR-641 expression in Huh7/DDP and Hep3B/DDP cells transfected with shNC, shLINC00173 or shLINC00173+miR-641 inhibitor. Cell Counting Kit-8 analysis to determine the IC₅₀ value of (C) Huh7/DDP and (D) Hep3B/DDP cells transfected with shNC, shLINC00173 or an shLINC00173+miR-641 inhibitor. TUNEL analysis (magnification, ×100) revealed the apoptosis of (E) Huh7/DDP and (F) Hep3B/DDP cells transfected with shNC, shLINC00173 or shLINC00173+miR-641 inhibitor. *P<0.05. DDP, cisplatin; miR, microRNA; HCC, hepatocellular carcinoma; RT-qPCR, reverse transcription-quantitative PCR; NC, negative control; sh, short hairpin; IC₅₀, half maximal inhibitory concentration.