Figure 8.

Loss-of-function Mediterranean G6PD variant prevents high-fat diet (HFD)-induced increases in Sperine1 and Epha4 expression and vascular resistance in rats. A: RT-PCR results showing that a HFD (4 mo) increased relative expression of Sperine1, Epha4, and Abra in aortas from wild-type rats but not Mediterranean G6PD variant rats. B: eating a HFD (4 mo) increased mean arterial pressure (MAP) and total peripheral resistance (TPR) in wild-type but not Mediterranean G6PD variant rats. n = 5 samples in each group. NC, normal chow.