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. 2021 Mar 18;14(3):dmm047589. doi: 10.1242/dmm.047589

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — MCPIP1 orchestrates autoimmunity by affecting TLR7 and TLR9 signaling. (A) Heat map depicting the altered genes from expression analysis of pre-selected genes in bone marrow-derived macrophages isolated from wild type and MCPIP1 knockouts and stimulated with R848 and CpG. Red marks the genes that were upregulated in knockouts upon stimulation. (B) Expression of selected genes was determined in bone marrow-derived macrophages 4 h post-stimulation with R848 and CpG. Data represent means±s.e.m.; *P<0.05, **P<0.01, ***P<0.001.