Figure 5.

G protein-coupled estrogen receptor 1 (GPER1) activation does not prevent glomerulosclerosis or proximal tubule dilation in high salt-fed female Dahl salt-sensitive (SS) rats. Representative images (A and B) and quantification of glomerular injury (C) and proximal tubule dilation (D) in female Dahl SS rats systemically treated with G1 (400 μg/kg/day) or vehicle (Veh) and fed a high-salt diet for 2 wk. Data are presented as means ± SE (n = 6 rats in each group). Statistical comparisons were performed by unpaired t test. Scale bars = 50 μm.