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Mechanisms involved in tissue-specific mineralocorticoid receptor (MR) activation in insulin resistance. Inappropriate MR activation promotes systemic and tissue insulin resistance through reduced insulin secretion, inflammation, oxidative stress, lipid disorders, decreased insulin and glucose uptake, as well as impaired insulin metabolic signaling. These abnormalities are prevented by MR antagonists. eNOS, endothelial nitric oxide (NO) synthase.
