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Synthesis of BINARI probes. Reagents and conditions: (i) Pd/C 10%, H2, MeOH, 40 °C, 48 h; (ii) NaNO2, H2O, H2SO4, 0 °C-100 °C, 30 min; (iii) TBDMSCl, imidazole, CH2Cl2, rt, 2h; (iv) NBS, AIBN, CCl4, 70 °C, 3 h; (v) NaN3, DMF, rt, 16 h; (vi) TBAF, THF, rt, 48 h; (vii) Tf(C2H4O2)n, DIPEA, CH2Cl2, 0 °C-rt, 2 h; (viii) NaOH, H2O, MeOH, rt, 16 h; (ix) CDI, DMSO, rt, 1 h.
