Table 2.
Quantification of the confidence of cell-to-clone assignment
Subject | Type | Method | Entropy | Gini index |
---|---|---|---|---|
S144 | Multiplet | CACTUS | 0.42 | 0.46 |
cardelino | 0.85 | 0.90 | ||
Singleton | CACTUS | 0.79 | 0.84 | |
cardelino | 0.87 | 0.90 | ||
S12118 | Multiplet | CACTUS | 0.04 | 0.04 |
cardelino | 0.39 | 0.45 | ||
Singleton | CACTUS | 0.36 | 0.38 | |
cardelino | 0.47 | 0.54 |
Confidence is measured as the concentration of the probability distribution of assigning a cell to clones, averaged across cells. Bolded values indicate which method (CACTUS or cardelino) obtained higher confidence. Both normalized entropy (entropy divided by the maximum possible value) and the Gini index are supposed to have lower values for more concentrated distributions, and larger values for more dispersed ones