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. 2021 Mar 24;12:204. doi: 10.1186/s13287-021-02244-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Therapeutic effect of MSC-Exo on OVA/CFA-induced SSRA in mice. a The experimental flowchart of construction of mouse model and MSC-Exo treatment. b The change of respiratory system resistance in response to different doses of methacholine. c The change of respiratory system resistance in response to 50 mg/ml methacholine. d The change of lung dynamic compliance in response to different doses of methacholine. e The change of lung dynamic compliance in response to 50 mg/ml methacholine. f Flow cytometry analysis of neutrophils (CD11b⁺Ly6G⁺) in BAL fluid. g H&E staining and histological score evaluation on lung tissues. Above: magnification, × 200; below: magnification, × 400. Data are presented as the mean ± SEM (n = 3) (#p < 0.05, ##p < 0.01, ###p < 0.001 vs. the control group; *p < 0.05, **p < 0.01, ***p < 0.001 vs. the OVA/CFA group)