Table 2.

Taxonomic identification at the phylum and genus levels in COPD

Phylum	LRE	HRE	p value	PFT I	PFT II	p value
Patients	60	18		43	35
Firmicutes	54.59 (41.54–73.32)	43.50 (31.63–60.68)	0.075	48.32 (40–66.09)	57.67 (38.70–69.2)	0.605
Actinobacteria	16.63 (8.48–28.24)	16.71 (11.58–22.79)	0.652	17.08 (8.62–27.99)	15.19 (10.11–24.00)	0.591
Proteobacteria	10.87 (1.69–22.06)	22.28 (8.70–37.70)	0.031	12.66 (1.90–21.82)	11.25 (5.96–24.55)	0.289
Bacteroidetes	3.26 (0.87–6.47)	3.98 (0.27–12.59)	0.610	3.51 (1.22–7.41)	3.18 (0.58–7.55)	0.706
Fusobacteria	2.00 (0.88–4.57)	2.95 (0.57–4.73)	0.585	2.36 (1.04–4.95)	1.65 (0.84–3.44)	0.083
Genera
Streptococcus	41.24 (28.72–60.15)	28.68 (22.91–35.54)	0.007	39.94 (28.61–60.65)	34.83 (25.70–49.55)	0.226
Rothia	10.83 (4.31–18.67)	10.20 (4.82–21.14)	0.859	10.86 (4.50–19.53)	10.51 (3.96–16.65)	0.543
Neisseria	3.07 (0.34–10.51)	3.42 (0.82–11.06)	0.400	3.04 (0.39–9.95)	4.21 (0.31–13.13)	0.393
Haemophilus	2.72 (0.19–6.43)	1.34 (0.22–11.76)	0.962	3.21 (0.23–6.41)	2.38 (0.16–11.69)	0.868
Granulicatella	2.54 (1.57–3.93)	2.95 (1.71–5.54)	0.343	2.54 (1.33–3.64)	2.86 (1.77–4.39)	0.317
Veillonella	1.45 (0.73–3.19)	2.25 (0.69–5.25)	0.226	1.73 (0.71–4.11)	1.64 (0.89–3.48)	0.956
Leptotrichia	1.30 (0.42–2.67)	1.14 (0.32–3.62)	0.840	1.67 (0.49–3.51)	0.96 (0.36–2.60)	0.353
Porphyromonas	0.96 (0.03–3.29)	0.94 (0.04–4.50)	0.677	1.03 (0.05–3.39)	0.78 (0.02–3.02)	0.790
Actinomyces	0.55 (0.19–1.35)	0.92 (0.34–1.48)	0.215	0.82 (0.19–1.43)	0.50 (0.25–1.26)	0.802
Capnocytophaga	0.37 (0.06–1.58)	0.61 (0.08–1.88)	0.585	0.46 (0.09–1.73)	0.42 (0.04–1.19)	0.457

Data are presented as median (25–75 percentile)

LRE low risk exacerbator, HRE high risk exacerbator, PFT pulmonary function test, PFT I FEV1 ≥ 50, PFT II FEV1 < 50.0

The p value is analyzed using Mann Whitney Wilcoxon test. Bonferroni-adjusted p-values < 0.05/15 (5 phylum and 10 genus) = 0.0033 indicate significance