Table 1.

Estimates of evolutionary divergence between patients’ HIV-1 proviral DNA sequences

	Patient 5A		Patient 10		Patients 5A + 10
	Median [min–max]	Mean	Median [min–max]	Mean	Median [min–max]	Mean
GALT
NGS	0.030 [0–0.189]	0.029	0.016 [0–0.098]	0.016	nd	nd
SGS	0.055 [0–0.088]	0.047	0.005 [0–0.013]	0.005	nd	nd
NGS + SGS	0.061 [0–0.119]	0.054	0.011 [0–0.065]	0.012	nd	nd
PBMC
NGS	0.053 [0–0.145]	0.051	0.013 [0–0.061]	0.013	nd	nd
SGS	0.047 [0–0.122]	0.051	0.013 [0–0.030]	0.013	nd	nd
NGS + SGS	0.065 [0.013–0,132]	0.065	0.016 [0–0.057]	0.017	nd	nd
GALT + PBMC
NGS	0.053 [0.008–0.143]	0.054	0.022 [0.003–0.095]	0.022	0.08 [0.047–0.214]	0.085

Evolutionary divergences are based on the number of base substitutions per site among RT NGS and/or SGS sequences obtained from GALT and/or PBMC proviral DNA of patients 5A and 10

nd not done, RT reverse transcriptase, GALT gut associated lymphoid tissue, PBMC peripheral blood mononuclear cells, NGS next generation sequencing, SGS single genome sequencing