Table 3.
OS and CSS in univariate and multivariate analyses
| Risk factors | OS | CSS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | |||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Age | 0.000 | 0.000 | ||||||
| > 30 | 1 | – | 1 | – | 1 | – | 1 | – |
| 30–39 | 1.71 (0.77–3.77) | – | 1.75 (0.79–3.87) | 0.166 | 1.39 (0.63–3.11) | – | 1.37 (0.61–3.05) | 0.447 |
| 40–49 | 1.86 (0.88–3.96) | – | 1.90 (0.89–4.05) | 0.095 | 1.48 (0.69–3.15) | – | 1.46 (0.68–3.11) | 0.332 |
| 50–59 | 2.55 (1.21–5.38) | – | 2.44 (1.15–5.14) | 0.020 | 1.94 (0.92–4.10) | – | 1.76 (0.83–3.72) | 0.139 |
| 60–69 | 3.80 (1.80–7.99) | – | 3.47 (1.65–7.32) | 0.001 | 2.63 (1.24–5.54) | – | 2.25 (1.06–4.75) | 0.034 |
| 70–79 | 6.63 (3.15–13.96) | – | 5.57 (2.64–11.74) | 0.000 | 4.07 (1.93–8.60) | – | 3.11 (1.47–6.57) | 0.003 |
| ≥ 80 | 12.97 (6.13–27.44) | – | 9.96 (4.70–21.10) | 0.000 | 7.58 (3.57–16.12) | – | 5.14 (2.41–10.95) | 0.000 |
| Sex | 0.024 | 0.902 | ||||||
| Female | 1 | – | 1 | – | 1 | – | – | – |
| Male | 1.10 (1.01–1.19) | – | 1.32 (1.21–1.44) | 0.000 | 1.01 (0.91–1.11) | – | – | – |
| Marital status | 0.000 | 0.000 | ||||||
| Married | 1 | – | 1 | – | 1 | – | 1 | – |
| Unmarrieda | 1.57 (1.45–1.71) | – | 1.33 (1.22–1.45) | 0.000 | 1.58 (1.43–1.74) | – | 1.27 (1.14–1.40) | 0.000 |
| Race | 0.000 | 0.000 | ||||||
| White | 1 | – | 1 | – | 1 | – | 1 | – |
| Black | 1.29 (1.15–1.45) | – | 1.41 (1.26–1.59) | 0.000 | 1.41 (1.23–1.61) | – | 1.47 (1.28–1.69) | 0.000 |
| Other | 0.73 (0.62–0.86) | – | 0.77 (0.65–0.90) | 0.001 | 0.86 (0.71–1.03) | – | 0.88 (0.73–1.05) | 0.161 |
| Tumor site | 0.048 | 0.000 | ||||||
| Right colonb | 1 | – | 1 | – | 1 | – | 1 | – |
| Left colonc | 1.09 (1.00–1.18) | – | 1.14 (1.04–1.24) | 0.003 | 1.21 (1.09–1.33) | – | 1.25 (1.13–1.39) | 0.000 |
| Tumor size | 0.001 | 0.016 | ||||||
| <5 | 1 | – | 1 | – | 1 | – | 1 | – |
| ≥ 5 | 1.15 (1.06–1.25) | – | 1.03 (0.95–1.12) | 0.494 | 1.13 (1.02–1.25) | – | 0.99 (0.89–1.10) | 0.864 |
| Histology | 0.000 | 0.001 | ||||||
| Adenocarcinoma | 1 | – | 1 | – | 1 | – | 1 | – |
| Mucinous adenocarcinoma | 1.14 (1.01–1.28) | – | 0.97 (0.86–1.10) | 0.668 | 1.14 (0.99–1.32) | – | 1.00 (0.87–1.16) | 0.964 |
| Signet ring cell carcinoma | 2.09 (1.43–3.06) | – | 1.34 (0.91–1.98) | 0.138 | 2.20 (1.42–3.42) | – | 1.45 (0.92–2.28) | 0.105 |
| Grade | 0.000 | 0.020 | ||||||
| I | 1 | – | 1 | – | 1 | – | 1 | – |
| II | 1.00 (0.84–1.19) | – | 1.06 (0.88–1.26) | 0.553 | 0.98 (0.79–1.20) | – | 1.04 (0.84–1.28) | 0.750 |
| III | 1.19 (0.98–1.45) | – | 1.13 (0.93–1.38) | 0.226 | 1.15 (0.92–1.45) | – | 1.13 (0.90–1.44) | 0.299 |
| IV | 1.54 (1.14–2.08) | – | 1.54 (1.14–2.09) | 0.005 | 1.33 (0.92–1.92) | – | 1.37 (0.95–1.99) | 0.095 |
| T stage | 0.000 | 0.000 | ||||||
| T3 | 1 | – | 1 | – | 1 | – | 1 | – |
| T4 | 2.88 (2.65–3.13) | – | 2.21 (2.02–2.41) | 0.000 | 3.20 (2.90–3.53) | – | 2.59 (2.33–2.87) | 0.000 |
| nLNd | 0.000 | 0.000 | ||||||
| 0 | 1 | – | 1 | – | 1 | – | 1 | – |
| 1–11 | 0.52 (0.39–0.70) | – | 0.56 (0.41–0.75) | 0.000 | 0.41 (0.30–0.57) | – | 0.48 (0.34–0.66) | 0.000 |
| ≥ 12 | 0.31 (0.23–0.42) | – | 0.38 (0.28–0.51) | 0.000 | 0.25 (0.19–0.35) | – | 0.33 (0.24–0.45) | 0.000 |
| CEAe | 0.000 | 0.000 | ||||||
| Positive | 1 | – | 1 | – | 1 | – | 1 | – |
| Negative | 0.51 (0.47–0.55) | – | 0.62 (0.57–0.67) | 0.000 | 0.50 (0.45–0.55) | – | 0.62 (0.56–0.69) | 0.000 |
aUnmarried, including single, widowed, divorced and separated;
bRight colon, including the cecum, the ascending colon, the hepatic flexure and the transverse colon;
cLeft colon, including the splenic flexure and the descending, sigmoid colons and rectosigmoid junction;
dnLN number of lymph nodes; eCEA carcinoembryonic antigen