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. Author manuscript; available in PMC: 2021 Mar 24.
Published in final edited form as: J Med Chem. 2020 Apr 22;63(10):5242–5256. doi: 10.1021/acs.jmedchem.0c00035

Table 1.

Inhibitory Rates of Series I Compounds on TLR3-Induced Expression of Inflammatory Genes in hSAECs at a Concentration of 10 μMa

graphic file with name nihms-1679942-t0002.jpg
compounds R1 R2 CIG5 (%) IL-6 (%)
7 5-OMe, 7-OMe H 86 ± 11 75 ± 8.6
10 H H −26 ± 3.1 81 ± 8.9
11 5-F H 33 ± 4.8 62 ± 7.2
12 6-F H −4.5 ± 0.6 62 ± 7.1
13 6-Cl H 37 ± 4.9 53 ± 5.6
14 6-Br H 43 ± 6.1 25 ± 3.4
15 7-Br H 51 ± 6.3 15 ± 1.9
16 7-(1-methyl-1H-pyrazol-3-yl) H 71 ± 8.5 −24 ± 2.8
19 7-NO2 CH3 −69 ± 7.4 86 ± 9.1
22 H CH3 18 ± 2.3 55 ± 6.5
a

Inhibitory rates (%) are reported as mean ± SD of expression in the compound divided by that in solvent (×100). Data are derived from three independent measurements (n = 3).