Table 3.

Inhibitory Rates of Series III Compounds on TLR3-Induced Expression of Proinflammatory Genes at a Concentration of 10 μM^a

Compounds	R4	CIG5 (%)	IL-6 (%)
3		84 ± 8.8	65 ± 5.7
37		83 ± 7.7	NTb
39		97 ± 10.5	98 ± 11.4
42		100 ± 9.8	100 ± 11
43		99 ± 11	99 ± 9.2
44		99 ± 12	100 ± 11
45		91 ± 10	97 ± 9.3
46		42 ± 5.1	82 ± 9.6
47		63 ± 7.5	88 ± 9.3
48		92 ± 11	99 ± 11
49		−19 ± 2.5	82 ± 7.7
50		85 ± 9.3	90 ± 8.6

^aInhibitory rates (%) are reported as the geometric mean of expression in the compound divided by that in solvent (×100). Data are derived from three independent measurements.

^bNT: Not tested.