Table 4.
IC50 Values of Selected Compounds against TLR3-Induced Expression of Inflammatory Genesa
compd | CIG5 (μM) | IL-6 (μM) |
---|---|---|
1 | 0.95 ± 0.11 | 1.02 ± 0.10 |
3 | 1.66 ± 0.15 | 3.29 ± 0.41 |
32 | 2.6 ± 0.22 | 3.5 ± 0.33 |
39 | 2.6 ± 0.21 | 2.8 ± 0.32 |
42 | 0.58 ± 0.49 | 0.54 ± 0.47 |
43 | 0.83 ± 0.07 | 0.75 ± 0.08 |
44 | 0.52 ± 0.05 | 1.1 ± 0.12 |
45 | 0.28 ± 0.03 | 0.31 ± 0.02 |
48 | 1.48 ± 0.17 | 0.97 ± 0.09 |
IC50 values are reported as the mean concentration (μM) derived from three independent measurements. Each titration curve was generated from at least eight different concentrations.