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. Author manuscript; available in PMC: 2021 Mar 24.
Published in final edited form as: J Med Chem. 2020 Apr 22;63(10):5242–5256. doi: 10.1021/acs.jmedchem.0c00035

Table 4.

IC50 Values of Selected Compounds against TLR3-Induced Expression of Inflammatory Genesa

compd CIG5 (μM) IL-6 (μM)
1 0.95 ± 0.11 1.02 ± 0.10
3 1.66 ± 0.15 3.29 ± 0.41
32 2.6 ± 0.22 3.5 ± 0.33
39 2.6 ± 0.21 2.8 ± 0.32
42 0.58 ± 0.49 0.54 ± 0.47
43 0.83 ± 0.07 0.75 ± 0.08
44 0.52 ± 0.05 1.1 ± 0.12
45 0.28 ± 0.03 0.31 ± 0.02
48 1.48 ± 0.17 0.97 ± 0.09
a

IC50 values are reported as the mean concentration (μM) derived from three independent measurements. Each titration curve was generated from at least eight different concentrations.