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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Mass Spectrom Rev. 2020 Jul 1;40(3):280–305. doi: 10.1002/mas.21642

FIGURE 5.

FIGURE 5.

Solidworks rendering of (A) the cryo-IM-MS source and (B) instrument with major components labeled. Ions generated by electrospray ionization are transferred to the heated capillary (red), which is heated to control the degree of hydration. Ions are then passed through the DC ion guide (green) and into the cryogenic IM drift tube (light blue). The kinetically trapped, hydrated ions are preserved as they pass through the drift tube by using drift gas precooled by liquid nitrogen circulating through the Dewar jacket (dark blue). After leaving the drift tube, the ions are detected by TOF mass analyzer. Instrument details are described in further detail elsewhere (Silveira et al., 2013b). TOF, time-of-flight.