Table 2.
Risk factors for invasive aspergillosis in SOT recipients. Herbrecht et al. [13] have listed the general risk factors for invasive fungal infections in haemato-oncological patients and solid organ transplant recipients, but the list is continuously increasing, and presently includes a number of additional factors [14–16], among them influenza, [17, 18]
Risk factors | References | |
---|---|---|
Heart | Reoperation; CMV infection; post-transplantation hemodialysis; presence of another patient with IA in the transplant program 2 months before or after the procedure; rejection, admission to the ICU, mechanical ventilation, and extracorporeal membrane oxygenation (ECMO) | [19, 20] |
Kidney | Bloodstream infections; pre-transplant chronic pulmonary obstructive disease; impaired graft function; long-term dialysis prior to transplantation; serious post-transplant infections | [21, 22] |
Liver | MELD score, choledochojejunostomy; anastomosis; bacterial infections in the first month and absence of antifungal prophylaxis; cytomegalovirus (CMV) reactivation; renal failure; hemodialysis; re-transplantation or transplantation for fulminant hepatic failure; reoperation | [5, 12, 22–24] |
Lung | Single lung transplantation; pre- and post-transplant colonization with Aspergillus spp., early airway ischemia, CMV infection, rejection | [25, 26] |