Table 2.

Association analysis of TFAS-based FA values of tracts of CC areas I–V with the clinical parameters (disease duration, ALS-FRS-R and UMN burden score).

	Clinical parameter	CC area I tracts	CC area II tracts	CC area III tracts	CC area IV tracts	CC area V tracts
C9orf72-associated ALS	Disease duration	−0.21	−0.09	−0.51*	−0.14	−0.11
	ALS-FRS-R	−0.04	0.12	0.40*	−0.19	−0.02
	UMN burden score	−0.02	−0.43*	−0.61*	0.00	−0.10
Sporadic ALS	Disease duration	0.25	0.09	−0.01	0.07	0.27
	ALS-FRS-R	0.23	0.39	0.43*	0.20	0.14
	UMN burden score	−0.36	−0.56*	−0.52*	−0.38	−0.31

^*Significant correlation.

ALS, amyotrophic lateral sclerosis ; ALS-FRS-R, revised ALS functional rating scale; CC, corpus callosum; FA, fractional anisotropy; TFAS, tractwise fractional anisotropy statistics; UMN, upper motor neuron.