Table 1.
Allele and genotype frequencies of the selected SNPs in the study cohort
| SNP (Gene) | Model | Genotype | Cases | Controls | OR (CI), p-value |
|---|---|---|---|---|---|
|
rs1532268 (c.524C > T) (MTRR) |
Dominant |
CT + TT CC |
86 35 |
75 46 |
0.25 (0.15–0.43), 2.4 × 10−7 |
| Recessive |
TT CT + CC |
14 107 |
3 118 |
5.15 (1.44–18.40), 0.005 | |
| Alleles |
T C |
0.41 0.59 |
0.2 0.8 |
5.73 (3.82–8.61), 5.11 × 10−7 | |
|
rs104894073 (c.886G > A) (GATA4) |
Dominant | GA + AA GG |
84 37 |
85 36 |
0.19 (0.11–0.32), 6.7 × 10−10 |
| Recessive |
AA GA + GG |
6 115 |
2 119 |
3.0 (0.61–15.70), 0.15 | |
| Alleles |
A G |
0.37 0.63 |
0.16 0.84 |
3.08 (2.00–4.74), 8.36 × 10− 8 | |
|
rs699947 (c.-2578C > A) (VEGF) |
Dominant | CA + AA CC |
103 18 |
71 50 |
0.25 (0.13–0.46), 4.7 × 10− 6 |
| Recessive | CA + CC AA |
95 26 |
105 16 |
1.80 (0.90–3.55), 0.089 | |
| Alleles |
A C |
0.53 0.47 |
0.36 0.64 |
2.03 (1.41–2.92), 0.0001 | |
|
rs6867206 (g.51356860 T > C) (ISL1) |
Dominant | TC + CC TT |
74 47 |
64 57 |
0.71 (0.43–1.19), 0.194 |
| Recessive | TC + TT CC |
121 0 |
121 0 |
– | |
| Alleles |
C T |
0.31 0.69 |
0.26 0.74 |
0.27 (0.85–1.89), 0.227 |