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. 2021 Mar 10;11:536346. doi: 10.3389/fonc.2021.536346

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Copyright © 2021 Zhou, Wang, Li, Qu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA APTR induced leiomyoma tumor cell proliferation. Ht-UtLM primary cells derived from leiomyoma tumors were used. (A) Stably infected Ht-UtLM cells were generated and identified. Real-time PCR analyses confirmed the efficiency. (B, C) Cell proliferation testing was conducted using MTT assays. APTR overexpression increased cell proliferation. Conversely, knocking down APTR decreased cell proliferation. (D, E) Colony-formation assays were performed on stably overexpressed or underexpressed APTR for 2 weeks. (F) Tumors from xenograft-transplanted nude mice 30 days after subcutaneously injecting APTR-overexpressing or control Ht-UtLM cells. (G) Xenograft volumes 30 days after cell injection. (H) Xenograft weights 30 days after cell injection.