Table 2.

Performance of different cut-offs/parametrizations of C-reactive protein (CRP) in a Cox model for time to mortality

CRP (mg/L) parametrization	Cohort 1 (Original)			Cohort 2 (Validation)
	N below cut-off (%)	Harrell’s C statistic	AIC	N below cut off (%)	Harrell’s C statistic	AIC
Null (CRP not included)	NA	0.6592	5224.41	NA	0.6816	428.58
CRP ≥ 10	132 (8.6%)	0.6697	5174.10	39 (15.2%)	0.6811	430.58
CRP ≥ 15	190 (12.4%)	0.6797	5159.14	56 (21.8%)	0.6995	429.22
CRP ≥ 20	230 (15.0%)	0.6858	5148.08	66 (25.7%)	0.7024	426.59
CRP ≥ 25	279 (18.2%)	0.6930	5144.01	75 (29.2%)	0.7055	427.83
CRP ≥ 30	326 (21.3%)	0.6953	5143.46	83 (32.3%)	0.7044	427.44
CRP ≥ 35	381 (24.9%)	0.6963	5141.06	91 (35.4%)	0.7145	425.61
CRP ≥ 40	439 (28.7%)	0.7024	5136.10	96 (37.4%)	0.7187	424.35
CRP ≥ 45	486 (31.7%)	0.7055	5132.53	103 (40.1%)	0.7015	427.18
CRP ≥ 50	530 (34.6%)	0.7059	5126.61	111 (43.2%)	0.6974	428.68
CRP ≥ 55	569 (37.1%)	0.7025	5130.50	120 (46.7%)	0.6900	428.85
CRP ≥ 60	605 (39.5%)	0.7064	5127.69	125 (48.6%)	0.6926	428.16
CRP ≥ 65	648 (42.3%)	0.7068	5124.45	129 (50.2%)	0.6867	428.47
CRP ≥ 70	687 (44.8%)	0.7033	5131.22	135 (52.5%)	0.6895	428.32
CRP ≥ 75	727 (47.5%)	0.7006	5131.79	139 (54.1%)	0.6879	428.87
CRP ≥ 80	766 (50.0%)	0.7005	5133.82	145 (56.4%)	0.6853	429.49
CRP ≥ 85	804 (52.5%)	0.7021	5135.11	155 (60.3%)	0.6887	429.16
CRP ≥ 90	834 (54.4%)	0.7001	5138.43	161 (62.6%)	0.6816	430.34
CRP ≥ 95	863 (56.3%)	0.6975	5142.08	169 (65.8%)	0.6828	429.98
CRP ≥ 100	887 (57.9%)	0.7010	5137.48	173 (67.3%)	0.6890	429.69
CRP (linear)	NA	0.7040	5024.81	NA	0.6992	426.42
log(CRP)	NA	0.7157	5001.00	NA	0.7014	426.51

Number of cases defined as not elevated CRP.

NA, not available.