Table 1.
Primate ACE2 Variants at Key Residues with Respect to the Human Wild-Type Amino Acid Sequence.a
| AA Position | Human Variants | Apes(6 sp.) | Old World Monkeys(20 sp.) | New World Monkeys(11 sp.) | Philippine Tarsier(1 sp.) | Prosimians(19 sp.) | |
|---|---|---|---|---|---|---|---|
| Endregion B | S19 | P | Ab | Fb | |||
| Q24 | Eb | ||||||
| T27 | A | Ab | Ab | Ab, Ib | |||
| D30 | Eb | ||||||
| K31 | Eb | Nb | |||||
| L79 | Rb | I | Rb, Ib | ||||
| M82 | I | Tc | S | Nd, Td | |||
| P84 | T | ||||||
| Middle | H34 | Q | Qb, Nb, Rb | ||||
| E35 | K, D | ||||||
| E37 | K | ||||||
| D38 | E | E | |||||
| Y41 | Hc | H | Hb | ||||
| Q42 | Lb | Ec | |||||
| Endregion A | Q325 | Rb | |||||
| N330 | Kb | ||||||
| K353 | N | Qb | |||||
| G354 | Qc | S | Db | ||||
| D355 | N |
a
Binding residues F28, L45, Y83, N90, T324, F356, R357, and R393 show no variants among the primates studied and so are not listed in the table.
b
Found in “only one or a few species of the group.”
c
Found in all the New World monkey species studied.
d
T is found at residue position 82 in 18 of the 19 prosimian species studied, whereas N is found in only 1 species.