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Common Alzheimer’s Disease Research Ontology (CADRO) with classes of AD therapeutic interventions (Refolo et al, 2012; Liggins et al, 2014).
| Amyloid | Metabolism and bioenergetics |
|---|---|
| Tau | Vasculature |
| Apolipoprotein, lipids, lipoprotein receptors | Growth factors and hormones |
| Neurotransmitter receptors | Synaptic plasticity/neuroprotection |
| Inflammation | Epigenetics |
| Oxidative stress | Neurogenesis |
| Proteostasis/proteinopathies | Other/multi-target |
