Table 3.
Models for COVID-19 Inpatient Test Positivity and COVID-19-Related Mortality With Inpatient Test-Confirmed COVID-19: M3 and M4
| M3: Age at the Pandemic (March 16, 2020) + Preexisting Diseases or Conditions at Baseline | M4: Age at the Pandemic (March 16, 2020) + Preexisting Disease or Conditions at Baseline + PhenoAgeAccel at Baseline | |||
|---|---|---|---|---|
| Positive (n = 613) vs Untested or Negative (n = 338 672) | Positive Dead (n = 151) vs Positive Alive, Untested or Negative (n = 339 108) | Positive (n = 613) vs Untested or Negative (n = 338 672) | Positive Dead (n = 151) vs Positive Alive, Untested or Negative (n = 339 108) | |
| Sex* (=male) |
1. 50 (1.28, 1.77)
p = 1.0e-06 |
1.96 (1.39, 2.75)
p = 1.1e-04 |
1.41 (1.19, 1.66)
p = 4.5e-05 |
1.69 (1.20, 2.38)
p = 2.9e-03 |
| Ethnicity† | ||||
| Black |
2.89 (1.93, 4.35)
p = 3.1e-7 |
3.11 (1.32, 7.29)
p = 9.2e-03 |
2.77 (1.84, 4.16)
p = 1.0e-06 |
2.92 (1.24, 6.88)
p = .014 |
| Other (incl. Asian, Chinese, and Mixed) |
1.94 (1.41, 2.68)
p = 5.4e-5 |
1.66 (0.79, 3.50) p = .18 |
1.94 (1.40, 2.67)
p = 5.8e-05 |
1.68 (0.80, 3.53) p = .17 |
| Age at the pandemic (per 5 years) |
1.07 (1.01, 1.13)
p = .019 |
1.81 (1.57, 2.10)
p = 1.6e-15 |
1.07 (1.02, 1.13)
p = 9.8e-03 |
1.82 (1.58, 2.11)
p = 6.1e-16 |
| PhenoAgeAccel (per 5 years) |
1.25 (1.16, 1.35)
p = 6.1e-09 |
1.50 (1.30, 1.73)
p = 3.1e-08 |
||
| Dementia (n1 = 0; n2 = 0) | ||||
| Type 2 diabetes (n1 = 41; n2 = 11) |
2.0 (1.43, 2.81)
p = 5.6e-05 |
1.54 (0.81, 2.93) p = .19 |
1.59 (1.12, 2.25)
p = 9.1e-03 |
1.02 (0.53, 1.98) p = .95 |
| History of pneumonia (n1 = 15; n2 = 3) | 1.07 (0.64, 1.8) p = .80 |
0.71 (0.22, 2.27) p = .57 |
1.04 (0.62, 1.76) p = .87 |
0.69 (0.22, 2.19) p = .53 |
| Depression (n1 = 64; n2 = 17) |
1.77 (1.36, 2.30)
p = 2.3e-05 |
1.98 (1.15, 3.40)
p = .014 |
1.71 (1.31, 2.23)
p = 6.9e-05 |
1.89 (1.10, 3.25)
p = .022 |
| Atrial fibrillation (n1 = 21; n2 = 8) |
1.68 (1.07, 2.64)
p = .024 |
1.77 (0.85, 3.69) p = .13 |
1.58 (1.01, 2.49)
p = .045 |
1.56 (0.74, 3.26) p = .24 |
| Hypertension (n1 = 250; n2 = 85) |
1.41 (1.18, 1.67)
p = 1.1e-04 |
1.91 (1.36, 2.67)
p = 1.7e-04 |
1.33 (1.12, 1.59)
p = 1.3e-03 |
1.73 (1.23, 2.43)
p = 1.5e-03 |
| COPD (n1 = 28; n2 = 13) |
1.88 (1.26, 2.80)
p = 1.8e-03 |
3.61 (1.98, 6.59)
p = 3.0e-05 |
1.74 (1.17, 2.59)
p = 6.6e-03 |
3.08 (1.68, 5.65)
p = 2.8e-04 |
| Chronic kidney disease (n1 = 4; n2 = 1) | 2.38 (0.87, 6.48) p = .091 |
1.99 (0.27, 14.56) p = .50 |
1.71 (0.62, 4.72) p = .30 |
|
| Liver disease (n1 = 11; n2 = 3) |
2.86 (1.55, 5.27)
p = 7.5e-04 |
3.37 (1.05, 10.75)
p = .04 |
2.61 (1.42, 4.82)
p = 2.1e-03 |
2.72 (0.85, 8.73)
p = .092 |
| Rheumatoid arthritis (n1 = 8; n2 = 4) | 0.93 (0.46, 1.88) p = .84 |
1.70 (0.62, 4.61) p = .30 |
0.80 (0.40, 1.62) p = .54 |
1.26 (0.46, 3.46) p = .65 |
| Coronary artery disease (n1 = 60; n2 = 19) | 1.18 (0.89, 1.58) p = .25 |
0.96 (0.58, 1.61) p = .88 |
1.14 (0.86, 1.53) p = .37 |
0.91 (0.54, 1.52) p = .72 |
| Delirium (n1 = 0; n2 = 0) | ||||
| Stroke (n1 = 5; n2 = 2) | 2.20 (0.90, 5.39) p = .083 |
2.57 (0.62, 10.59) p = .19 |
2.16 (0.88, 5.27) p = .092 |
2.47 (0.60, 10.19) p = .21 |
| Asthma (n1 = 84; n2 = 13) | 1.05 (0.83, 1.33) p = .69 |
0.52 (0.28, 0.96)
p = .035 |
1.02 (0.80, 1.29) p = .89 |
0.49 (0.26, 0.90)
p = .022 |
| Previous falls/fragile fractures (n1 = 26; n2 = 6) |
1.73 (1.16, 2.57)
p = 6.8e-03 |
1.20 (0.49, 2.94) p = .69 |
1.69 (1.14, 2.52)
p = 9.2e-03 |
1.14 (0.46, 2.80) p = .77 |
| Osteoarthritis (n1 = 69; n2 = 24) | 1.09 (0.84, 1.41) p = .51 |
1.19 (0.75, 1.87) p = .46 |
1.07 (0.83, 1.38) p = .62 |
1.15 (0.73, 1.80) p = .56 |
Notes: In bold if p < .05; assessment center results skipped; n1: number of inpatient positives between March 16 and April 27, 2020; n2: number of COVID-19-related deaths following an inpatient positive result between March 16 and April 27, 2020.
*Reference: female.
†Reference: White.