Table 4.
Models for COVID-19 Inpatient Test Positivity and COVID-19-Related Mortality With Inpatient Test-Confirmed COVID-19: M5 and M6
| M5: Age at the Pandemic (March 16, 2020) + Preexisting Diseases or Conditions to March 2020 | M6: Age at the Pandemic (March 16, 2020) + Preexisting Diseases or Conditions to March 2020 + PhenoAgeAccel at Baseline | |||
|---|---|---|---|---|
| Positive (n = 613) vs Untested or Negative (n = 338 672) | Positive Dead (n = 151) vs Positive Alive, Untested or Negative (n = 339 108) | Positive (n = 613) vs Untested or Negative (n = 338 672) | Positive Dead vs Positive Alive, Untested or Negative (n = 338 108) | |
| Sex* (=male) |
1.41 (1.19, 1.66)
p = 6e-05 |
1.76 (1.24, 2.49)
p = 1.6e-03 |
1.37 (1.16, 1.62)
p = 2.0e-04 |
1.66 (1.17, 2.37)
p = 4.6e-03 |
| Ethnicity† | ||||
| Black |
2.59 (1.71, 3.90)
p = 6.1e-06 |
2.39 (1.00, 5.68)
p = .049 |
2.56 (1.69, 3.86)
p = 8.1e-06 |
2.34 (0.98, 5.59) p = .055 |
| Other (incl. Asian, Chinese, and Mixed) |
1.81 (1.30, 2.50)
p = 3.8e-04 |
1.38 (0.65, 2.94) p = .40 |
1.82 (1.31, 2.52)
p = 3.3e-04 |
1.42 (0.67, 3.02) p = .37 |
| Age at the pandemic (per 5 years) | 0.95 (0.90, 1.00) p = .057 |
1.46 (1.26, 1.69)
p = 3.9e-07 |
0.95 (0.90, 1.01) p = .09 |
1.48 (1.28, 1.71)
p = 1.7e-07 |
| PhenoAgeAccel (per 5 years) |
1.10 (1.02, 1.19)
p = .016 |
1.21 (1.04, 1.40)
p = .011 |
||
| Dementia (n1 = 60; n2 = 31) |
5.56 (4.00, 7.74)
p = 2.5e-24 |
7.20 (4.37, 11.86)
p = 9.0e-15 |
5.62 (4.04, 7.82)
p = 1.2e-24 |
7.35 (4.46, 12.11)
p = 4.7e-15 |
| Type 2 diabetes (n1 = 131; n2 = 52) |
1.65 (1.32, 2.05)
p = 9.9e-06 |
2.04 (1.39, 2.99)
p = 2.6e-04 |
1.54 (1.23, 1.93)
p = 2.1e-04 |
1.80 (1.21, 2.67)
p = 3.7e-03 |
| History of pneumonia (n1 = 112; n2 = 41) |
2.27 (1.79, 2.89)
p = 1.4e-11 |
2.28 (1.48, 3.50)
p = 1.7e-04 |
2.24 (1.76, 2.84)
p = 3.9e-11 |
2.20 (1.43, 3.39)
p = 3.3e-04 |
| Depression (n1 = 104; n2 = 31) |
1.38 (1.10, 1.73)
p = 5.3e-03 |
1.50 (0.97, 2.31) p = .07 |
1.37 (1.09, 1.72)
p = 6.1e-03 |
1.50 (0.97, 2.32) p = .068 |
| Atrial fibrillation (n1 = 99; n2 = 36) |
1.47 (1.15, 1.88)
p = 2.3e-03 |
1.29 (0.84, 1.97) p = .24 |
1.46 (1.14, 1.87)
p = 2.7e-03 |
1.27 (0.83, 1.95) p = .26 |
| Hypertension (n1 = 352; n2 = 118) |
1.47 (1.22, 1.77)
p = 6.0e-05 |
2.22 (1.46, 3.38)
p = 2e-04 |
1.44 (1.19, 1.74)
p = 1.3e-04 |
2.15 (1.41, 3.28)
p = 3.5e-04 |
| COPD (n1 = 71; n2 = 29) | 1.21 (0.92, 1.61) p = .18 |
1.69 (1.06, 2.69)
p = .028 |
1.18 (0.89, 1.57) p = .24 |
1.61 (1.01, 2.57)
p = .047 |
| Chronic kidney disease (n1 = 72; n2 = 29) |
1.66 (1.26, 2.19)
p = 3.6e-04 |
1.65 (1.04, 2.61)
p = .032 |
1.57 (1.18, 2.08)
p = 1.7e-03 |
1.48 (0.93, 2.36) p = .10 |
| Liver disease (n1 = 36; n2 = 6) | 1.27 (0.89, 1.81) p = .19 |
0.61 (0.26, 1.43) p = .26 |
1.25 (0.87, 1.78) p = .23 |
0.58 (0.24, 1.37) p = .21 |
| Rheumatoid arthritis (n1 = 26; n2 = 12) | 1.16 (0.77, 1.75) p = .47 |
1.60 (0.84, 3.07) p = .15 |
1.12 (0.74, 1.68) p = .60 |
1.46 (0.76, 2.82) p = .26 |
| Coronary artery disease (n1 = 133; n2 = 47) | 1.03 (0.83, 1.29) p = .79 |
0.98 (0.66, 1.44) p = .90 |
1.03 (0.82, 1.28) p = .83 |
0.96 (0.65, 1.43) p = .85 |
| Delirium (n1 = 40; n2 = 19) |
1.79 (1.21, 2.66)
p = 3.8e-03 |
1.85 (1.01, 3.38)
p = .045 |
1.79 (1.21, 2.66)
p = 3.9e-03 |
1.85 (1.01, 3.39)
p = .045 |
| Stroke (n1 = 30; n2 = 11) |
1.41 (0.95, 2.08)
p = .089 |
1.30 (0.68, 2.49) p = .43 |
1.39 (0.94, 2.06)
p = .10 |
1.26 (0.66, 2.43) p = .48 |
| Asthma (n1 = 117; n2 = 24) | 1.09 (0.88, 1.35) p = .42 |
0.71 (0.44, 1.13) p = .15 |
1.09 (0.88, 1.35) p = .45 |
0.70 (0.44, 1.13) p = .14 |
| Previous falls/fragile fractures (n1 = 140; n2 = 48) |
1.87 (1.50, 2.32)
p = 2.3e-08 |
1.68 (1.11, 2.54)
p = .014 |
1.85 (1.49, 2.31)
p = 3.5e-08 |
1.65 (1.09, 2.50)
p = .018 |
| Osteoarthritis (n1 = 80; n2 = 28) | 0.84 (0.65, 1.07) p = .16 |
0.89 (0.58, 1.38) p = .61 |
0.83 (0.65, 1.07) p = .15 |
0.89 (0.58, 1.37) p = .60 |
Notes: In bold if p < .05; assessment center results skipped; n1: number of inpatient positives between March 16 and April 27, 2020; n2: number of COVID-19-related deaths following an inpatient positive result between March 16 and April 27, 2020.
*Reference: female.
†Reference: White.