Figure 1.

HP infection significantly reduced the number of platelets in murine models. (A) Platelet counts were enumerated before each anti-CD41 antibody injection. (B) Enzyme-linked immunosorbent assay (ELISA) for anti-HP antibody detection. (C) Representative histopathology images from stomach tissue on day 5. (D) Bone marrow cell smears were taken out to observe the morphology and primary classification of megakaryocytes (megakaryoblast, granular megakaryocytes, and plate megakaryocytes). (E) Effects of SSI on spleen Index and thymic Index in ITP Model mice. (Spleen index = spleen weight/mouse body weight (g) × 100%); Thymus index=thymus weight/mouse weight (g) ×100%. All data represent mean ± SEM; n =6; *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 versus vehicle. Analysis of Variance (ANOVA) and Student’s t-test (two-tailed).