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. 2021 Mar 19;13:339–344. doi: 10.2147/JEP.S297682

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© 2021 Quadri et al.

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(A) Biology and signaling of (pro)renin receptor. Representative schematic organization. (B) (Pro)renin receptor (PRR) signaling pathways. Activation/upregulation of PRR induces kidney damage via ERK1/2, MAPK, NF-ҡB, TNF-α pathway.