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Schematic representation of the mechanism underlying LT. In general, light exerts its function through visual and non-visual perception pathways. As the circadian master, SCN regulates clock gene oscillations, thus synchronizing multiple central and peripheral structures. LT: Light therapy; SCN: Suprachiasmatic nucleus; ipRGCs: Intrinsically photosensitive retinal ganglion cells; AP-1: Activator protein-1; ROS: Reactive oxygen species; NF-κB: Nuclear factor-κB.
