Figure 4. Sequence comparison of Tau residues around phospho Ser396 epitope in rodents and humans.
Comparison between Tau sequences from rat, mouse and human around the serine-phosphorylation site (gray arrow) probed by the anti-Tau phospho S396 antibody (Ser396 analog in rat is Ser388; in mouse is S369). Considering the differences in reactivity and biochemical nature of side chains, the positions where significant substitutions are present comparing rodent versus human sequences are indicated by yellow arrows. The default color scheme of AliView was used in the alignment.