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A basic pathway of antigen processing for cell surface presentation. A proteasome processes cytosolic proteins, including foreign proteins from viral infections and phagocytosis. The process generates short peptides, which are transported into the endoplasmic reticulum. There, they bind MHC-I molecules. The pMHC assembly is transported through the Golgi apparatus to the cell surface. There, the assembly can engage the TCR of a CD8+ cell.
