Fig 2.

Allele-competition results for the KR (A and B) and CKR (C and D) experiments. Frequency of the kdr allele was significantly reduced from generation F₁ to F₉ for both KR (A) and CKR (C). The SS genotype (homozygous susceptible, white bars) increased significantly from generation F₃ to F₇ for both KR (B) and CKR (D), but was not significantly different from F₃ to F₉ for the KR experiment (B). The RR genotype changed significantly from F₃ to F₇ in the CKR experiment (B), but there was no significant difference in the KR experiment (D). Frequency of heterozygotes (RS) did not change between generations. Different letters represent significant differences (p < 0.05) of the susceptible and kdr alleles (A and C) or the SS, RS, and RR genotypes (B and D) across generations only. Shaded area around the line represent 95% CI (A and C) and bars represent the standard error (B and D).