Fig 6. diMF is not synthetic lethal with a variety of other oncoproteins.

Rat1A cells harboring either an empty vector or one of the indicated oncogenes, were treated with either 0.1% DMSO (□), 6 μM diMF ($■$) or 300 nM VX-680 ($■$) for 3 days. Cell viability, was assayed using the trypan blue exclusion assay. Each data point is the average of three independent experiments, with treatments done in triplicate (n = 9). Error bars denote standard deviation. For cells overexpressing MYC and the N1ICD, viability of the diMF and VX-680 groups was statistically different from DMSO (one-way ANOVA followed by Dunnett’s test). The symbol * indicates p<0.01 for drug treated compared to DMSO control.