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. 2021 Mar 24;16(3):e0248355. doi: 10.1371/journal.pone.0248355

Fig 7. MYC-diMF synthetic lethality is not due to a general priming of apoptosis.

Fig 7

Cells overexpressing (RPE-MYC) or not overexpressing (RPE-NEO) MYC were treated for 72 hours with various chemical primers of apoptosis: DCB (2μg/ml), VX-680 (300 nM), Paclitaxel (5 μM), Nocodazole (1μg/ml), Eg5 inhibitor II (10μM), Monastrol (20 μM), Doxorubicin (200 nM), Cisplatin (200 μM), Etoposide (20 μM), Zeocin (50 μg/ml), Cycloheximide (10 μg/ml), Staurosporine (10 μM), serum withdrawal and 0.1% DMSO as a control group. Cell viability was assayed by trypan blue exclusion assay. Each column represents the average of three independent experiments, with three replicates in each experiment (n = 9). Error bars denote standard deviation. Viability differences between RPE-NEO and RPE-MYC cells with each chemical were statistically compared using two tailed, unpaired t-tests. The symbol * indicates p<0.01.