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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Hypertension. 2021 Feb 22;77(4):1061–1068. doi: 10.1161/HYPERTENSIONAHA.120.14513

Figure 1. Working model: labelled-line encoding of feeding, BP and RMR control in the ARC.

Figure 1.

Evidence supports the working hypothesis that a specific subset of AgRP neurons express the AT1A receptor (Agtr1a), and that these receptors simultaneously (i) identify the subset of AgRP neurons involved in RMR control, and (ii) serve a critical molecular role in the integrative control of RMR. We hypothesize that molecular dysfunctions specifically within the Agtr1a-expressing subset of AgRP neurons contributes to the development of SLR and weight loss-associated adaptations in RMR control. Pomc, proopiomelanocortin; αMSH, α-melanocyte stimulating hormone; Mc4r, melanocortin type 4 receptor; Agrp, Agouti-related peptide; ANG, angiotensin II; BAT SNA, brown adipose tissue sympathetic nerve activity; RMR, resting metabolic rate.