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. 2021 Mar 12;15(3):e0009258. doi: 10.1371/journal.pntd.0009258

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© 2021 White et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Tracking the molecular specificity of DV2 TS nAbs to epitopes on EDIII in sera from TDV vaccinated NHPs (A), WT DV2 infected NHPs (B), TDV vaccinated, baseline seronegative adults (C) or adults who had a DV2 natural infection (D). Neut50 titers to parental viruses DV2 (EDIII epitope donor), DV4 (backbone recipient of epitope transplant) and chimeric virus DV4/2EDIII (DV2 EDIII transplanted into DV4 E protein) were determined in sera collected 180 days after infection or vaccination (A, B, C). Sera used in (D) were collected in subjects pre-TDV vaccination, with evidence of past primary DENV2 infection based on Neut50 titers to DV2 > 4-fold higher than those to the other 3 serotypes. (A) (B) and (D) show titers in control-depleted (BSA-D) and DV4-depleted sera. (C) shows titers in undepleted sera. Horizontal lines and error bars represent GMT +/- 95% CI. Dotted line represents lower limit of detection.