Table 2. Sub-analysis for Richmond agitation-sedation scale—4 / - 5 patients: Homogeneity and comparison of demographic data and characteristics between groups.
| Survivor Group n = 4 | Non—Survivor Group n = 7 | p-value | |
|---|---|---|---|
| Sex (Male) | 2 (50%) | 7 (100%) | 0.109 |
| Sex (Female) | 2 (50%) | 0 (0%) | |
| Age (years) | 62 (60; 71) | 71 (57; 72) | 0.788 |
| Weight (kg) | 78 (73; 91) | 85 (75; 99) | 0.527 |
| SOFA | 2.5 (2; 6) | 8 (3; 9) | 0.055 |
| RASS | -4 (-4.75; -4) | -5 (-5; -4) | 0.156 |
| CRP (mg.dl-1) | 6.1 (2.2; 188.5) | 112 (26; 309) | 0.256 |
| IL-6 (pg.ml-1) | 153.3 (0.24; 1.65) | 963 (702; 1350) | 0.439 |
| Procalcitonin (ng.ml-1) | 0.6 (0.24; 1.65) | 0.33 (0.12; 0.68) | 0.506 |
| Midazolm | 3 (75%) | 5 (71%) | 1.000 |
| Propofol | 1 (25%) | 1 (14%) | 1.000 |
| Dexmedetomidine | 1 (25%) | 2 (29%) | 1.000 |
| Fentanil | 1 (25%) | 1 (14%) | 1.000 |
| Remifentanil | 0 (0%) | 2 (29%) | 0.491 |
| Morphine | 2 (50%) | 4 (57%) | 1.000 |
| Lidocaine | 2 (50%) | 1 (14%) | 0.491 |
| Neuromusc. blockade | 1 (25%) | 6 (86%) | 0.088 |
| Noradrenaline | 0 (0%) | 3 (43%) | 0.236 |
| Dobutamine | 0 (0%) | 0 (0%) | 1.000 |
| VCV mode | 3 (75%) | 6 (86%) | 1.000 |
| PCV mode | 1 (25%) | 1 (14%) | |
| FiO2 | 0.75 (0.7; 0.8) | 1 (0.8; 1) | 0.017 |
| Tidal Volume (ml) | 480 (420; 510) | 480 (450; 520) | 0.848 |
| Resp. rate (rpm) | 18 (16.5; 18) | 20 (18; 20) | 0.067 |
| PEEP (cmH2O) | 9 (7.25; 10) | 10 (9; 12) | 0.145 |
| PaO2 (mmHg) | 265.3 (129.7; 309.9) | 124 (81.2; 137) | 0.059 |
| ANIm | 61.5 (52.3; 73) | 93 (89; 99) | 0.008 |
| ANIi | 63 (58.3; 79.8) | 94 (87; 99) | 0.014 |
| Energy (ms) | 0.62 (0.38; 0.74) | 0.18 (0.13; 0.71) | 0.186 |
Basic descriptives and tests for the demographic and characteristics variables for each group. Absolute (N) and relative (%) frequencies for the qualitative variables, and median and quartiles (1st; 3rd) for the quantitative variables. P-values were calculated using Mann—Whitney U test. SOFA, Sequential Organ Failure Assessment; RASS, Richmond Agitation-Sedation Scale; CRP, C-reactive protein; IL-6, Interleukin-6; VCV, Volume-controlled ventilation; FiO2, Fraction of inspired oxygen; PEEP, positive end-expiratory pressure; PaO2, partial pressure of oxygen in arterial blood; ANIm, mean analgesia nociception index; ANIi, instantaneous analgesia nociception index.