. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Int Rev Neurobiol. 2020 Oct 17;156:1–62. doi: 10.1016/bs.irn.2020.08.005

Table 3.

Effects of adolescent alcohol exposure on histone acetylation mechanism.

Study	Species	Exp.	Region	Genes	Mark(s)	Findings
(Pandey et al., 2015)	Sprague Dawley rats	Intermittent, 2g/kg i.p.	CeA, MeA	Hdac2, Hdac4, Bdnf-I, Bdnf-IV, Arc	H3K9ac, H3K9/14ac	- Decreased H3K9ac and increased HDAC2 and HDAC4. - Increased HDAC activity
						- TSA prevents molecular effects, anxiety and alcohol consumption
(Sakharkar et al., 2016)	Sprague Dawley rats	Intermittent, 2g/kg i.p.	Hipp.	Ki-67, DCX, Bdnf-I, Bdnf-IV, CBP	H3K9ac, H3K9/14ac	- Decreased H3K9ac and CBP in CA1–3 regions, -Increased HDAC activity
						- TSA prevents anxiety, restores markers of neurogenesis and decreases of H3K9/14ac at BDNF-I and BDNF-IV promoters
(Mulholland et al., 2018)	Sprague Dawley rats	5g/kg i.g.	Hipp.	Fmr1	H3K9/14ac,H3K27ac	- Donepezil prevents increases of Fmr1 mRNA and increased H3K27ac at Fmr1 gene
(Bohnsack et al., 2019)	Humans	Earlyage of onset	Amgydala	BDNF, Arc	H3K27ac	- Decreased Arc and BDNF expression and decrease in H3K27ac at regulatory elements
(Zhang et al., 2018)	Sprague Dawley rats	Intermittent 2g/kg i.p.	CeA, MeA	CBP, P300, CREB	H3K9/14Ac	- Decreased CBP, P300, and CREB expression
						- Decreased H3K9/14ac at promoters of CBP, P300, and CREB.

Abbreviations: Exp. = exposure, i.p. = intraperitoneal, i.g. = intragastric, CeA = central nucleus of the amygdala, MeA = medial nucleus of the amygdala, Hipp = hippocampus.