Table 7.

Effects of fetal alcohol exposure on histone methylation mechanism.

Study	Species	Exp.	Region	Genes	Mark(s)	Findings
(Govorko et al., 2012)	Sprague Dawley rats	Liquid alcohol diet	Hypo.	Set7, G9A, Setdb1	H3K4me2, H3K4me3, H3K9me2	- Decreased H3K4me2, H3K4me3, and Set7 in the arcuate area of the hypothalamus
						- Increased H3K9me2, G9A and Setdb1 in the arcuate area of the hypothalamus
(Bekdash et al., 2013)	Sprague Dawley rats	Liquid alcohol diet	Hypo.	Set7/9A, G9A, Setdb1	H3K4me2/3, H3K9me2, H3K9Ac	- Choline administration prevents decreases in H3K4me2/3 and Set7/9
						- Choline administration prevents increases in H3K9me2 and G9A and Setdb1
(Subbanna et al., 2013)	C57BL/6	i.p. 2.5 g/kg	Hipp. NeoCtx	G9A, CC3, and Tau	H3K9me2, H3K27me3	- Increased G9A expression, H3K9me2 and H3K27me3, and G9A activity in neocortex and hippocampus
						- Treatment with G9A inhibitor prevents increases in Tau and CC3 protein
(Subbanna et al., 2014)	C57BL/6	i.p. 1 g/kg	Hipp. NeoCtx	G9A, CC3, and Tau	H3K9me2, H3K27me3	- Increased G9A, expression H3K9me2 and H3K27me3 and G9A activity in neocortex and hippocampus
						- Treatment with G9A inhibitor prevents increases in Tau and CC3 protein
(Subbanna et al., 2015)	C57BL/6	i.p 2.5 g/kg	Hipp. NeoCtx	Cb1	H3K9me2	- Decreased H3K9me2 associated with Cb1 promoter
(Veazey et al., 2015)	C57BL/6	i.p 2.9 g/kg	Cortex	24 genes	H3K4me3, H3K27me3, H3K9me2	- Broadly, H3K27me3 was decreased and H3K9me2 was increased associated with genes in animals with craniofacial deformities

Abbreviations, Exp = exposure, i.p. = intraperitoneal, Hyp = hypothalamus, hipp = hippocampus, NeoCtx = Neocortex.