Table 8.

dCas9 constructs for use in target epigenetic engineering.

Study	Cas9	Effector	Target	Effect	Addgene
(Hilton et al., 2015)	S. pyogenes	P300	Histone Acetylation	Gene Activation	61357
(Kearns et al., 2015)	S. pyogenes	LSD1	Demethylates H3K4 and 9 me1, 2	Gene Repression	92362
(Liu et al., 2016)	S. pyogenes	TET1	DNA demethylation	Gene Activation	84475
(Liu et al., 2016)	S. pyogenes	DNMT3A	DNA methylation	Gene Repression	84570
(Kwon et al., 2017)	S. pyogenes	HDAC3	Histone Acetylation	Gene Repression	98591
(Chen, Lin et al., 2019)	S. pyogenes	HDAC8	Histone Acetylation	Gene Repression	n/a
(O’Geen et al., 2017)	S. pyogenes	EZH2	Writer of H3K27me3	Gene Repression	100086
(O’Geen et al., 2017)	S. pyogenes	G9A	Writer of H3K9me3	Gene Repression	100089