Fig. 5.

Using CTD Anatomy to help inform exposure data. The same anatomy vocabulary is used to annotate both chemical-phenotype and exposure data, and CTD Anatomy webpages coalesce this heterogeneous information, allowing experimental results to be connected to and help inform real-world outcomes. On the Tibia webpage, the “Chemical-Phenotype Interactions” data-tab (top) describes the role of lead in osteoclast and bone development in the tibia of mice, while the “Exposure Studies” data-tab (bottom) report how long-term cumulative lead exposure in humans (24.9 µg per gram tibia) correlates with excessive tooth loss. Users can leverage these data to generate testable hypotheses (middle) for potential molecular mechanisms and adverse outcome pathways to help fill in the knowledge gaps for environmental health; in this example, lead interacts with 20 known genes (from the Inference Network) to modulate bone phenotypes, which in turn could be related to tooth loss.