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. 2021 Mar 24;7(13):eabc9992. doi: 10.1126/sciadv.abc9992

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — (A) Chemical structure of CHI-C and schematic illustration of the preparation of the CHI-C sponge. Photo credit: Keumyeon Kim, KAIST and InnoTherapy Inc. (B) UV-vis and (C) ¹H-NMR spectra of CHI-C. (D) A photographic image of the blood protein barrier (BpB) membrane formed by CHI-C in human whole blood. Photo credit: Keumyeon Kim, KAIST and InnoTherapy Inc. (E) A photographic image of BpB membranes (right vial, red arrows) formed by CHI-C in human plasma. However, no BpB membrane was formed by chemically unmodified chitosan (left vial). Photo credit: Keumyeon Kim, KAIST and InnoTherapy Inc. (F) Scanning electron microscope (SEM) images of the surface (top) and cross section (bottom) of the BpB membrane at predetermined immersion times (3 min, 3 hours, and 12 hours). a.u., absorbance unit.