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. 2021 Apr 1;12(2):441–465. doi: 10.14336/AD.2020.0910

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copyright: © 2021 Adlimoghaddam et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 11. — Bay11-7082 decreased mitochondrial respiration rates in 3xT-AD astroglia. (A) Kinetics graph indicating real-time OCR at baseline and after addition of oligomycin, FCCP, and rotenone/antimycin. The OCR was measured in 3xTg-AD astroglia utilizing the XF24 analyzer after 24 hours treatment with Bay11- 7082 (1, 3, 5, and 10 uM). (B) Basal respiration, (C) maximal respiration and (D) spare respiratory capacity, and (E) coupling efficiency were calculated compared between control and treated cells. Data are mean ± SD of n = 5 group (** = p < 0.01) analyzed by unpaired Student's t-test.