Table 2.
Overall estimates of maternal characteristics, treatment profile, and outcomes
| Case series | Case reports | P-value | |
|---|---|---|---|
| Proportion (95% CI) | Proportion (95% CI) | ||
| Maternal Characteristics | |||
| Age (years) mean (95% CI) | 30.60 (28.90, 32.40)a | 31.10 (29.97, 32.24) | 0.359 |
| BMI (Kg/m2) mean (95% CI) | 29.40 (27.30, 31.70)a | 35.81 (32.04, 39.57) | < 0.001 |
| Gestational age (weeks) mean (95% CI) | 31.30 (28.80, 33.80)a | 32.70 (31.31, 34.24) | 0.050 |
| Symptomatic presentation | 0.89 (0.75, 0.98) | 0.89 (0.78, 0.95) | 0.006 |
| Comorbidities | |||
| Diabetes mellitus | 0.04 (0.03, 0.07) | 0.23 (0.12, 0.39) | < 0.001 |
| Hypertension | 0.04 (0.02, 0.07) | 0.09 (0.03, 0.22) | 0.283 |
| Asthma | 0.04 (0.02, 0.06) | 0.09 (0.03, 0.22) | 0.131 |
| Obesity | 0.09 (0.04, 0.15) | 0.29 (0.16, 0.46) | < 0.001 |
| Treatment | |||
| Oxygen support | 0.33 (0.20, 0.47) | 0.53 (0.40, 0.66) | < 0.001 |
| Steroids | 0.06 (0.00, 0.19) | 0.44 (0.31, 0.57) | < 0.001 |
| Immunosuppressants | 0.01 (0.00, 0.03) | 0.10 (0.04, 0.20) | 0.004 |
| Hydroxychloroquine | 0.10 (0.03, 0.19) | 0.26 (0.16, 0.38) | 0.082 |
| Antivirals | 0.33 (0.18, 0.49) | 0.45 (0.32, 0.58) | < 0.001 |
| Zinc/Magnesium | 0.02 (0.00, 0.14) | 0.21 (0.12, 0.34) | 0.007 |
| Anticoagulants | 0.03 (0.00, 0.07) | 0.12 (0.05, 0.23) | 0.031 |
| Antibiotics | 0.36 (0.21, 0.52) | 0.64 (0.51, 0.76) | < 0.001 |
| Plasma therapy/Anti-liver damage | 0.02 (0.00, 0.06) | 0.14 (0.07, 0.26) | < 0.001 |
| Mechanical ventilation | 0.03 (0.01, 0.07) | 0.35 (0.23, 0.49) | < 0.001 |
| Maternal & Pregnancy Outcomes | |||
| ICU admission | 0.06 (0.02, 0.10) | 0.43 (0.31, 0.57) | < 0.001 |
| Hospital length of stay (days) mean (95% CI) | 8.47 (5.96, 10.97)a | 14.6 (12.0, 17.2) | < 0.001 |
| Maternal death | 0.003 (0.00, 0.02) | 0.05 (0.01, 0.13) | 0.108 |
| Cesarean section | 0.62 (0.54, 0.71) | 0.69 (0.56, 0.80) | 0.085 |
| Fetal demise | < 1% | 0.08 (0.03, 0.19) | 0.003 |
| Neonatal death | < 1% | 0.02 (0.00, 0.08) | 0.143 |
| Premature birth | 0.26 (0.19, 0.34) | 0.50 (0.37, 0.63) | < 0.001 |
aWeighted mean reported; I2 % measure of heterogeneity, CI confidence interval, ICU intensive care unit, NA not applicable, BMI body mass index