Table 1.
Cohort characteristics.a
| Characteristics | NHW CN | NHW AD | AA CN | AA AD | Diagnosis p-valueb | Race p-valueb |
|---|---|---|---|---|---|---|
| Sex | 3 F, 2 M | 4 F, 2 M | 0 F, 4 M | 2 F, 3 M | 0.301 | 0.065 |
| Agec | 65 ± 13 | 83 ± 8 | 69 ± 15 | 80 ± 6 | 0.011 | 0.986 |
| Years of Educationd | 17 | 15 ± 4 | 8 | 13 | 0.572 | 0.050 |
| PMIe | 14 ± 9 | 6 ± 2 | 13 ± 9 | 11 ±7 | 0.142 | 0.479 |
| APOE Genotypef | 4 ε3/ε3, 1 ε2/ε2 | 5 ε3/ε3, 1 ε3/ε4 | 1 ε3/ε3, 3 N/A | 1 ε3/ε3, 2 ε3/ε4, 2 ε4/ε4 | – | – |
| Aβ A4 Positive | 4 N 1 Y, rare |
6 Y | 2 N 1 Y, rare 1 Y |
5 Y | – | – |
| Braak Stageg | 1 (0–2) | 4 (4–5) | 1 (0–2) | 5 (4–5) | < 0.0001 | 0.698 |
a
Values for each group are given as average ± standard deviation, unless otherwise noted.
b
p-values were calculated using two-factor ANOVAs with replication; bold indicates p < 0.05.
c
Age in years.
d
Years of education was not available for all individuals. Averages and standard deviations were calculated from available samples for each group (NHW CN: N = 2; NHW AD: N = 6; AA CN: N = 1; AA AD: N = 2).
e
Postmortem interval (PMI), in hours.
f
N/A indicates genotype was unavailable.
g
Average Braak stage (range). Abbreviations: NHW, non-Hispanic White; AA, African American/Black.